MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS

The disclosure describes compounds of Formula la, which in non-limiting aspects contain an asialoglycoprotein receptor (ASGPR) binding moiety and an anti-piAR binding moiety. Compounds of Formula la are useful in preventing, treating, and/or ameliorating heart failure in a subject when administered...

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Bibliographische Detailangaben
Hauptverfasser:	SPIEGEL, David, CAIANIELLO, David, DERAMON, Edward
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The disclosure describes compounds of Formula la, which in non-limiting aspects contain an asialoglycoprotein receptor (ASGPR) binding moiety and an anti-piAR binding moiety. Compounds of Formula la are useful in preventing, treating, and/or ameliorating heart failure in a subject when administered in therapeutically effective amounts.