BISPECIFIC MOLECULE SPECIFICALLY BINDING TO B7-H3 AND TGFΒ AND USES THEREOF

The present invention relates to a B7-H3 antibody or an antigen-binding fragment thereof; and a bispecific molecule comprising a TGFβ-binding site binding thereto and uses thereof and, more particularly, to a bispecific molecule that can be used as an immune checkpoint inhibitor for various diseases...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, Jung Wook, PARK, Dong Woon, LEE, Jung Eun, JUNG, Byung Hun
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a B7-H3 antibody or an antigen-binding fragment thereof; and a bispecific molecule comprising a TGFβ-binding site binding thereto and uses thereof and, more particularly, to a bispecific molecule that can be used as an immune checkpoint inhibitor for various diseases including cancer by bispecifically binding to B7-H3 and TGFβ.