HUMAN TRANSFERRIN RECEPTOR-BINDING ANTIBODY-PEPTIDE CONJUGATE

[Problem] To provide an art for crossing the blood-brain barrier. [Solution] A conjugate comprising the following: (1) a transferrin receptor-binding peptide, wherein (i) the peptide contains the amino acid sequence from the 1st to the 15th (Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Arg-Arg-Tyr-MeY-Cy...

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Hauptverfasser: OHUCHI Masaki, FUJIYAMA Saki, YODEN Eiji, INABA Shinnosuke, HASHIMOTO Hidehiko, TAKAHASHI Kenichi, SAWAI Naoki
Format: Patent
Sprache:eng
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Zusammenfassung:[Problem] To provide an art for crossing the blood-brain barrier. [Solution] A conjugate comprising the following: (1) a transferrin receptor-binding peptide, wherein (i) the peptide contains the amino acid sequence from the 1st to the 15th (Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Arg-Arg-Tyr-MeY-Cys) of the amino acid sequence given by SEQ ID NO: 1; (ii) the peptide has an amino acid sequence exhibiting a substitution, deletion, addition, and/or insertion of from 1 to 11 amino acid residues in the amino acid sequence from the 1st to the 15th of the amino acid sequence given by SEQ ID NO: 1; (iii) the peptide contains the amino acid sequence from the 1st to the 12th (Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Ser-Cys) of the amino acid sequence given by SEQ ID NO: 14; or (iv) the peptide has an amino acid sequence exhibiting a substitution, deletion, addition, and/or insertion of from 1 to 8 amino acid residues in the amino acid sequence from the 1st to the 10th of the amino acid sequence given by SEQ ID NO: 14, and (2) a compound containing an antibody or an antigen-binding fragment thereof.