BISPECIFIC ANTI-FLT3/CD3 ANTIBODIES AND METHODS OF USE

BISPECIFIC ANTI-FLT3/CD3 ANTIBODIES AND METHODS OF USE

Provided herein are bispecific anti-FLT3/CD3 antibodies and antigen binding fragments thereof, such as the antibodies and fragments that specifically bind human FLT3 and human CD3. In some aspects, provided herein are optimized humanized, bispecific anti-FLT3/CD3 antibodies and antigen binding fragm...

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Bibliographische Detailangaben
Hauptverfasser: LIANG, Raymond, ADER, Max Ephraim, SHRESTHA, Elina, SIROCHINSKY, Carina Rachel, SANDLER, Vladislav M, BEN JEHUDA, Ronen, KORYTKO, Andrew Ihor, CHILTON, Todd Christopher, SKORA, Andrew Dixon
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided herein are bispecific anti-FLT3/CD3 antibodies and antigen binding fragments thereof, such as the antibodies and fragments that specifically bind human FLT3 and human CD3. In some aspects, provided herein are optimized humanized, bispecific anti-FLT3/CD3 antibodies and antigen binding fragments thereof, optionally, having certain amino acid substitutions that confer advantageous properties (e.g., optimal antigen binding, manufacturability and/or half-life properties). Also provided herein are pharmaceutical compositions comprising such antibodies or fragments. Also provided herein are methods of use of such antibodies and fragments.