1'-ALKYL MODIFIED RIBOSE DERIVATIVES AND METHODS OF USE

The present disclosure provides linker compounds of Formula (I) or (II) pharmaceutically acceptable salts thereof, and related scaffolds and conjugates. More specifically, linker compounds of formulas (l-A), (Il-A) are provided: The present disclosure also relates to uses of the linker compounds, sc...

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Bibliographische Detailangaben
Hauptverfasser:	CAI, Xiaochuan, WANG, Weimin
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Beschreibung
Zusammenfassung:	The present disclosure provides linker compounds of Formula (I) or (II) pharmaceutically acceptable salts thereof, and related scaffolds and conjugates. More specifically, linker compounds of formulas (l-A), (Il-A) are provided: The present disclosure also relates to uses of the linker compounds, scaffolds, and conjugates, e.g., in delivering nucleic acid and/or treating or preventing diseases.