Target peptides for immunotherapy and diagnostics

Target peptides for immunotherapy and diagnostics

A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the 5 proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in...

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Bibliographische Detailangaben
Hauptverfasser: OBENG, Rebecca C, HUNT, Doland F, CUMMINGS, Kara L, MALAKER, Stacey A, ENGELHARD, Victor H, ZARLING, Angela, COBBOLD, Mark, SHABANOWITZ, Jeffrey
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A set of target peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of disease cells. They are envisioned to among other things (a) stimulate an immune response to the 5 proliferative disease, e.g., cancer, (b) to function as immunotherapeutics in adoptive T cell therapy or as a vaccine, (c) facilitate antibody recognition of tumor boundaries in surgical pathology samples, (d) act as biomarkers for early detection and/or diagnosis of the disease, and (e) act as targets in the generation antibody-like molecules which recognize the target-peptide/MHC complex. -314-