MATERIALS AND METHODS FOR IMMUNE EFFECTOR CELLS REDIRECTION

A molecule comprising a first means for engaging or activating a Natural Killer (NK) cell, and a second means for binding a tumor cell, wherein the molecule is capable of inducing NK cell dependent cytotoxicity against the tumor cell. A molecule comprising, among other things, natural killer cell engagers including anti-NKG2d molecules, anti-NKp46 molecules, and multispecific molecules comprising the same or fragments thereof, as well as nucleic acids and expression vectors encoding the molecules, recombinant cells containing the vectors, and compositions comprising the molecules.