PYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (

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Bibliographische Detailangaben
Hauptverfasser:	HESSE, Matthew James, COBB, Jennifer Stroka, CERNIJENKO, Artiom, DEWHURST, Janetta, KERRIGAN, John Ryan, TING, Pamela YF, MANNING, James R, JAIN, Rama, THOMSEN, Noel Marie-France, O'BRIEN, Gary, DALES, Natalie Alysia, PATTERSON, Andrew W, BONAZZI, Simone, MALIK, Hasnain Ahmed
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (