HETEROCYCLIC DERIVATIVES AS JANUS KINASE INHIBITORS

The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the inve...

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Bibliographische Detailangaben
Hauptverfasser: ACCETTA, Alessandro, RIZZI, Andrea, ZADRAVEC, Rahela, RANCATI, Fabio, ŽIHER, Dinko, CUZZOLIN, Alberto, ELENKOV, Ivaylo, MESIĆ, Milan
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.