Neural network parameter quantization for base calling

A method of quantizing parameters of a neural network includes grouping a plurality of parameters of a neural network in a plurality of groups. Each group of the plurality of groups includes corresponding two or more parameters of the plurality of parameters. In an example, for each group, a corresponding quantization format is selected from a plurality of available quantization formats, such that a first quantization format selected for at least a first group is different from a second quantization format selected for at least a second group. For each group, individual parameters within the corresponding group are quantized using the quantization format selected for the corresponding group. The quantized parameters of the plurality of groups are stored in a memory.