Nitrile-containing antiviral compounds

Nitrile-containing antiviral compounds

Nitrile-Containing Antiviral Compounds The invention relates to compounds of Formula I" q' R2 O (R), I", wherein R, R1, R 2, R 3, p, q and q' are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID 19 in...

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Bibliographische Detailangaben
Hauptverfasser: SAMMONS, Matthew Forrest, WEI, Liuqing, REESE, Matthew Richard, TUTTLE, Jamison Bryce, YANG, Qingyi, VERHOEST, Patrick Robert, PETTERSSON, Martin Youngjin, OWEN, Dafydd Rhys, YANG, Xiaojing
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Nitrile-Containing Antiviral Compounds The invention relates to compounds of Formula I" q' R2 O (R), I", wherein R, R1, R 2, R 3, p, q and q' are as defined herein, pharmaceutical compositions comprising the compounds, methods of treating coronavirus infection such as COVID 19 in a patient by administering therapeutically effective amounts of the compounds, and methods of inhibiting or preventing replication of coronaviruses such as SARS CoV-2 with the compounds.