ANTIBODIES TARGETING THE SPIKE PROTEIN OF CORONAVIRUSES

Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclo...

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Hauptverfasser:	DOUEK, Daniel Cesar, MISASI, John, MASCOLA, John R, PEGU, Amarendra, ZHOU, Tongqing, ZHANG, Yi, KWONG, Peter D, MASON, Rosemarie Diana, SHI, Wei, SULLIVAN, Nancy J, LEDGERWOOD, Julie E, YANG, Eun Sung, ROEDERER, Mario, WANG, Lingshu, SCHRAMM, Chaim Aryeh, HENRY, Amy Ransier
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are monoclonal antibodies, antigen binding fragments, and bi-specific antibodies that specifically bind a coronavirus spike protein, such as SARS-CoV-2. Also disclosed is the use of these antibodies for inhibiting a coronavirus infection, such as a SARS-CoV-2 infection. In addition, disclosed are methods for detecting a coronavirus, such as SARS-CoV-2, in a biological sample, using the disclosed antibodies.