LACTAMS AS CBL-B INHIBITORS

Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same. Representative lactam compounds include molecules falling within the following formulae:

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Bibliographische Detailangaben
Hauptverfasser:	JAKALIAN, Araz, YADAV, Arun, BROCCATELLI, Fabio, LAMBRECHT, Michael John, LAROUCHE-GAUTHIER, Robin, WANG, Xiaojing, LIANG, Jun, UNG, Man Un, ZBIEG, Jason Robert, HUESTIS, Malcolm
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Various lactam compound that binds Cbl-B, many of which are selective for Cbl-B over C-Cbl, and methods of making and using the same. Representative lactam compounds include molecules falling within the following formulae: