A conjugate of a tubulysin analog with branched linkers

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched linkage method of conjugation of a...

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Hauptverfasser:	ZHAO, Robert Yongxin, LI, Wenjun, GAI, Shun, ZHUO, Xiaotao, ZHENG, Jun, HUANG, Yuanyuan, JIA, Junxiang, YANG, Qingliang, ZHANG, Xiuzheng, CAI, Xiang, ZHOU, Xiaomai, GUO, Huihui, XU, Yifang, LEI, Jun, TONG, Qianqian, ZHAO, Linyao, XIE, Hongsheng, YE, Hangbo, BAI, Lu, CAO, Mingjun
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.