IMPLANTABLE PHARMACEUTICAL COMPOSITION PREPARED FROM COMPONENTS CONSISTING ONLY OF CALCIUM SULFATE α-HEMIHYDRATE, VANCOMYCIN AND GENTAMICIN

Abstract The present invention concerns a composition for an implantable pharmaceutical composition prepared from components consisting only of calcium sulfate a-hemihydrate in combination with two antibiotics, vancomycin and gentamicin, for the treatment of infection in bone and soft tissue. Figure...

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Bibliographische Detailangaben
Hauptverfasser:	Laycock, Phillip Anthony, Harris, Michael Christopher James, Aiken, Sean Sydney, Cooper, John Joseph, Bratt, John Stephen
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Abstract The present invention concerns a composition for an implantable pharmaceutical composition prepared from components consisting only of calcium sulfate a-hemihydrate in combination with two antibiotics, vancomycin and gentamicin, for the treatment of infection in bone and soft tissue. Figure 1 Bead dissolution (6mm bead in 10 ml Phosphate Buffered Saline) n=10 lo 80.0 o60.0 co ,a r-4 (N M LnU LO r, 00 M 0) 1)-1 (N M Ln If) 1,, 00 a~ ) 0 r-.J m4 M 1.t Ln c 00 M 0~ -1 -4 J m 3- in 1.0 (V ~iI~ - 4, -i --I (NI r-4 " (N "N (4 (4 M MN MN M m M m Day -4-Sample A Sample B Sample C Figure 2 3/s Figure 3 Figure 4 SECTION A-A Figure 5 GQ~ % Q0-0% C %Q Q % G