Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET Kinases

Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET Kinases

Provided herein are compounds of the Formula I: R2 -NO and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R, R 2, R9, X 1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention...

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Bibliographische Detailangaben
Hauptverfasser: HINKLIN, Ronald Jay, ALLEN, Shelley, LAIRD, Ellen, COOK, Adam, NULTY, Oren T, BARBOUR, Patrick, ZHAO, Qian, DAHLKE, Joshua, GAUDINO, John
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided herein are compounds of the Formula I: R2 -NO and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R, R 2, R9, X 1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.