Aldosterone synthase inhibitor

Aldosterone synthase inhibitor

Abstract The present invention relates to a compound selected from (R)-(+)-5-(p-cyanophenyl) 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and a pharmaceutically acceptable saltthereof, and in 5 particular to the phosphate salt of (R)-(+)-5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5 a]pyridine, both h...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: STEELE, Ronald Edward, SCHUMACHER, Christoph, FUHRER, Walter
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Abstract The present invention relates to a compound selected from (R)-(+)-5-(p-cyanophenyl) 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine and a pharmaceutically acceptable saltthereof, and in 5 particular to the phosphate salt of (R)-(+)-5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5 a]pyridine, both having preferably an enantiomeric excess of the (R) form higher than or equal to 97%. Furthermore, the present invention relates to pharmaceutical compositions comprising the same, their use as a medicament and in methods of treatment of diseases and disorders in humans including women of child bearing potential and pediatric patients in which aldosterone 0 over-exposure contributes to the deleterious effects of said diseases or disorders, as well as processes for preparing said inventive compounds. 11255763_1 (GHMatters) P111063.AU