PROCESSES FOR THE PREPARATION OF 4-{8-AMINO-3-[(2S)-1-(BUT-2-YNOYL)-PYRROLIDIN-2-YL]IMIDAZO[1,5-A]-PYRAZIN-1-YL}N-(PYRIDIN-2-YL)-BENZAMIDE

PROCESSES FOR THE PREPARATION OF 4-{8-AMINO-3-[(2S)-1-(BUT-2-YNOYL)-PYRROLIDIN-2-YL]IMIDAZO[1,5-A]-PYRAZIN-1-YL}N-(PYRIDIN-2-YL)-BENZAMIDE

The present disclosure relates, in general, to improved processes for the preparation of 4-{8 amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yllimidazoll,5-alpyrazin-1-ylI-N-(pyridin-2-y1) benzamide, particularly large-scale processes for manufacturing 4-{8amino-3-[2S)-1-(but-2 ynoyl)pyrrolidin-2-yl]imid...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Cox, Robert John, Garrey, Rustam Ferdinand, Bethel, Paul Allen, Short, David Allen, Telford, Alexander James, Zijp, Eric Jurriën, Jackson, Lucinda Victoria, Cooper, Katie Grace, Van Eijk, Peter Johannes Servaas Savio, Junying, Qiu, Hughes, Shaun Alan, Verstappen, Mathilda Maria Henrica, Lawler, Michael Joseph, Evarts, Jerry, Millard, Kirsty Jane, Vos, Frank L.M, Chan, Lai Chun, Litjens, Remy E.J.N, Wang, Angang, Golden, Michael David, Phillips, Andrew John
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present disclosure relates, in general, to improved processes for the preparation of 4-{8 amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yllimidazoll,5-alpyrazin-1-ylI-N-(pyridin-2-y1) benzamide, particularly large-scale processes for manufacturing 4-{8amino-3-[2S)-1-(but-2 ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.