METHOD FOR MANUFACTURING AN INHALABLE POWDER COMPRISING VORICONAZOLE

The present invention relates to a method for manufacturing an inhalable powder comprising leucine and voriconazole or a pharmaceutically active salt thereof, in substantially crystalline form, in an amount greater than 50% by weight with respect to the total weight of the powder. The method compris...

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Bibliographische Detailangaben
Hauptverfasser:	ZANELOTTI, Laura, MAGGI, Loretta, CAPONETTI, Giovanni, CASTEGINI, Franco, NICOSIA, Valentina, FAIELLA, Gianluigi, MAGI, Nadia
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a method for manufacturing an inhalable powder comprising leucine and voriconazole or a pharmaceutically active salt thereof, in substantially crystalline form, in an amount greater than 50% by weight with respect to the total weight of the powder. The method comprises a first step consisting of providing a solution of voriconazole or pharmaceutically active salt thereof and leucine in a suitable vehicle, a second step consisting in drying said powder using the spray drying technique at an outlet temperature from 40 and 75°C and at a feed rate greater than 10 g/minute and finally collecting the powder obtained.