IONIZABLE CATIONIC LIPIDS AND LIPID NANOPARTICLES, AND METHODS OF SYNTHESIS AND USE THEREOF

Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

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Bibliographische Detailangaben
Hauptverfasser: NIELSEN, Ulrik, BOESCH, Austin Wayne, ALI, Mir, DRUMMOND, Daryl Clark, KUHLMAN, William
Format: Patent
Sprache:eng
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Zusammenfassung:Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.