HETERODIMERIC PSMA AND CD3-BINDING BISPECIFIC ANTIBODIES

HETERODIMERIC PSMA AND CD3-BINDING BISPECIFIC ANTIBODIES

The present disclosure relates to antibodies that specifically bind to a tumor-associated antigen (TAA) such as PSMA and/or CD3, including bispecific antibodies that bind to a TAA (e.g., PSMA( and CD3, and compositions comprising the same. These antibodies are useful for enhancing immune responses a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PAVLIK, Peter, MISHER, Lynda, GROSS, Jane, BIENVENUE, David Leonard, HERNANDEZ-HOYOS, Gabriela
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure relates to antibodies that specifically bind to a tumor-associated antigen (TAA) such as PSMA and/or CD3, including bispecific antibodies that bind to a TAA (e.g., PSMA( and CD3, and compositions comprising the same. These antibodies are useful for enhancing immune responses and for the treatment of disorders, including solid tumor cancers, for example, by increasing tumor localization.