Preparation method for S-configuration phenylethylamine hydrochloride compound

The present invention relates to the technical field of the synthetic preparation for medicines, and relates to a preparation method for an S-configuration phenylethylamine hydrochloride compound. The preparation method comprises the following steps: step (1), performing a Friedel-Crafts reaction on m-dimethoxybenzene and acetyl chloride under a Lewis acid condition to generate an intermediate A; (2) reacting the intermediate A with hydroxylamine hydrochloride, without isolating the intermediate A, to generate an intermediate B; step (3), reducing the intermediate B under a reducing agent condition to obtain a compound C; step (4) resolving the compound C by means of an organic acid to obtain an organic salt of an S-configuration compound D; and step (5) dissociating the organic salt and then performing saltification to obtain a target product compound E. The preparation method of the present invention has the characteristics of simple purification, low cost, high efficiency, high yield and suitability for industrial mass production.