COMBINATION OF AN ANTIBODY-DRUG CONJUGATE WITH ANTI-SIRPα ANTIBODY

Provided are a pharmaceutical composition and a treatment method that are excellent in terms of antitumor effect and safety. A pharmaceutical composition and a treatment method characterized in that an antibody-drug conjugate, in which a drug linker shown by the formula (in the formula, A represents...

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Bibliographische Detailangaben
Hauptverfasser:	TSUBAKI Takuya, ISHIMOTO Yoko, SUE Mayumi
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided are a pharmaceutical composition and a treatment method that are excellent in terms of antitumor effect and safety. A pharmaceutical composition and a treatment method characterized in that an antibody-drug conjugate, in which a drug linker shown by the formula (in the formula, A represents the binding site with the antibody) and an antibody are bonded by a thioether bond, is administered in combination with an SIRPα-CD47 interaction inhibitor such as an anti-SIRPα antibody, etc. Also, a pharmaceutical composition and a treatment method characterized in that the antibody-drug conjugate and an SIRPα-CD47 interaction inhibitor such as an anti-SIRPα antibody, etc., are administered in combination and used to treat a disease which is improved by the action of activating antitumor immunity.