COMPOUNDS FOR TARGETED PROTEIN DEGRADATION OF KINASES

The present invention relates to bifunctional compounds for targeted kinase degradation, methods for treating diseases or conditions mediated by aberrant kinase activity, and methods for identifying degradable kinases and optimal kinase: scaffold pairs.

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Bibliographische Detailangaben
Hauptverfasser:	GRAY, Nathanael S, RYU, SeongShick, DONOVAN, Katherine, FISCHER, Eric S, SIM, Taebo, BHUNIA, Debabrata, BUSHMAN, Jonathan W, FERGUSON, Fleur M
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to bifunctional compounds for targeted kinase degradation, methods for treating diseases or conditions mediated by aberrant kinase activity, and methods for identifying degradable kinases and optimal kinase: scaffold pairs.