ORTHOGONAL IL-21 RECEPTOR/CYTOKINE SYSTEMS

ORTHOGONAL IL-21 RECEPTOR/CYTOKINE SYSTEMS

Orthogonal IL-21 receptors and orthogonal IL-21 cytokines are described. The IL-21 receptor-cytokine pairs may include an orthogonal interleukin-21 receptor a chain ("ortho-IL- 21Rα") that has impaired binding to native interleukin-21 cytokine ("IL-21") and an orthogonal IL-21 cy...

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Bibliographische Detailangaben
Hauptverfasser: VOLLRATH, Benedikt, KILLEEN, Nigel, GOVINDARAJAN, Sridhar, BESKE, Oren
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Orthogonal IL-21 receptors and orthogonal IL-21 cytokines are described. The IL-21 receptor-cytokine pairs may include an orthogonal interleukin-21 receptor a chain ("ortho-IL- 21Rα") that has impaired binding to native interleukin-21 cytokine ("IL-21") and an orthogonal IL-21 cytokine ("ortho-IL-21") that has impaired binding to native IL-21Ra, wherein the ortho- IL-21 Ra binds to the ortho-IL-21. The IL-21 receptor-cytokine pair may activate IL-21 signaling. Cells engineered to express the orthogonal IL-21 receptors are also described, as well as methods for using such cells for treatment of various diseases and disorders.