INTERLEUKIN-2-FC FUSION PROTEINS AND METHODS OF USE

INTERLEUKIN-2-FC FUSION PROTEINS AND METHODS OF USE

Provided are serum half-life extended-IL-2 variant (IL-2v) heterodimers having reduced binding to the IL2Rα (CD25) subunit. In particular, Fc-IL-2v heterodimers are provided and methods for making and using, e.g. for enhancing an immune response,

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Bibliographische Detailangaben
Hauptverfasser: PAPALIA, Giuseppe, BACA, Manuel, GILMORE, Sarah A, MUKHERJEE, Prasenjit K, TAM, Danny W, JAVANBAKHT, Hassan, HUNG, Magdeleine S, KHAN, Shahzada, THOMAS, Majlinda K, KANWAR, Manu, NAGEL, Mark R
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:Provided are serum half-life extended-IL-2 variant (IL-2v) heterodimers having reduced binding to the IL2Rα (CD25) subunit. In particular, Fc-IL-2v heterodimers are provided and methods for making and using, e.g. for enhancing an immune response,