A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE

A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE

The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Comp...

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Hauptverfasser: SFOUGGATAKIS, Chris, KOSCHKER, Philipp, PEREGO, Luca Alessandro, SKLIAR, Dimitri, EASTGATE, Martin D, RAHMANI, Ramdane, LUO, Helen Y, REUTER, Karl, SCHMALZBAUER, Björn, MUKHERJEE, Subha, WEI, Carolyn S, XIOURAS, Christos, MATCHA, Kiran, JAMISON, Christopher Robert, CAO, Duy Chi Trung, KOLOTUCHIN, Sergei, TRAN, Ngoc Duc, WAGSCHAL, Simon Albert, MOWER, Matthew Penfield, SINGH, Amarjit, WISNIEWSKI, Steven R, ORTIZ, Adrian, ZHENG, Bin, BROGGINI, Diego Fernando Domenico, CUNIERE, Nicolas, GALLAGHER, William P, CHERNICHENKO, Kostiantyn, LEMAIRE, Sébastien François Emmanuel, JUSSEAU, Xavier Jean-Marie, BEN HAÏM, Cyril, ZHDANKO, Alexander
Format: Patent
Sprache:eng
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APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one: Compound (I).