MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharma...

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Hauptverfasser:	KHATUYA, Haripada, HADIDA RUAH, Sara Sabina, MCCARTNEY, Jason, CLEVELAND, Thomas, FANNING, Lev Tyler Dewey, ABRAHAM, Sunny, SILINA, Alina, KRENITSKY, Paul, PIERRE, Fabrice, COON, Timothy Richard, VALDEZ, Lino, ISHIHARA, Yoshihiro, ZHOU, Jinglan, VICKERS, Troy, PARASELLI, Prasuna, MILLER, Mark Thomas, ARUMUGAM, Vijayalaksmi, TRAN, Joe A, DWIGHT, Timothy A, GROOTENHUIS, Peter, FRIEMAN, Bryan A, ANDERSON, Corey Don, UY, Johnny, MELILLO, Vito, CLEMENS, Jeremy, ABELA, Alexander Russell, CHAU, Jaclyn, GULEVICH, Anton V
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies employing those modulators, and processes and intermediates for making such modulators.