Systems and methods of detecting incorrect connections in a humidification system

Various control methods can indirectly determine incorrect connections between components in a respiratory therapy system. For example, incorrect connections can occur between a patient interface, a humidifier, and/or a gases source. The methods can indirectly detect if reverse flow conditions or other error conditions exist. A reverse flow condition can occur when gases flows in a direction different from an intended direction of flow. The methods can be implemented at the humidifier side, at the gases source side, or both.