METHOD OF PURIFICATION OF RECOMBINANTLY-PRODUCED RSV PROTEINS IN TRIMERIC FORM

The invention relates to a purification method of a recombinantly-produced RSV Fprotein in trimeric form.According to the invention, the method sequentially comprises an anion exchangechromatography step, a cHA chromatography step and a HIC step.The invention is also directed to a pharmaceutical pro...

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Hauptverfasser:	KOH, Eun Hee, YUAN, Yonghui, CAI, Ping, YE, Xinhao, ZHAO, Jay Zhixing, WEAVER, Michele L, VIDUNAS, Eugene Joseph
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to a purification method of a recombinantly-produced RSV Fprotein in trimeric form.According to the invention, the method sequentially comprises an anion exchangechromatography step, a cHA chromatography step and a HIC step.The invention is also directed to a pharmaceutical product including an RSV F protein purified by such a method.