Marine bacterial exopolysaccharide derivatives and uses thereof in the treatment of mucopolysaccharidoses

Marine bacterial exopolysaccharide derivatives and uses thereof in the treatment of mucopolysaccharidoses

The invention provides low-molecular-weight over-sulfated polysaccharides with anti-heparanase activity prepared from marine native exopolysaccharides excreted by mesophilic marine bacteria from a deep-sea hydrothermal environment and relates to the use of these low-molecular-weight over-sulfated po...

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Bibliographische Detailangaben
Hauptverfasser: ZOUGGARI, Nawel, COLLIEC-JOUAULT, Sylvia, TILLE, Jean-Christophe, DE AGOSTINI, Ariane, ZYKWINSKA, Agata, SINQUIN, Corinne, DENTANT-QUADRI, Isabelle, VERALDI, Noémi, MBOSSO BEFFORT, Jennifer
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides low-molecular-weight over-sulfated polysaccharides with anti-heparanase activity prepared from marine native exopolysaccharides excreted by mesophilic marine bacteria from a deep-sea hydrothermal environment and relates to the use of these low-molecular-weight over-sulfated polysaccharides for the prevention or treatment of mucopolysaccharidoses, in particular mucopolysaccharidoses type III (Sanfilippo syndrome).