6-6 Fused Bicyclic Heteroaryl Compounds and their use as LATS inhibitors

C:\Usersczg\AppDaa\Roa ing\iManagc\Work\Rcen t\35570725AU 6-6 fusedbicywlIc, eroa l yco pounds ad thr us asLATS hibitor\Abstract as, field - 35570725(22281273 1).docx-7 12/2021 6-6 Fused Bicyclic Heteroaryl Compounds and their Use as LATS Inhibitors The present invention is related to 6-6 Fused Bicy...

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Hauptverfasser:	JIN, Qihui, PAN, Jianfeng, LIU, Yahu, MAIBAUM, Juergen Klaus, TCHORZ, Jan, YAN, Shanshan, XIE, Yun Feng, LACOSTE, Arnaud, HAO, Xueshi, ZOU, Yefen, MO, Tingting, BEHNKE, Dirk, HOFFMAN, Timothy, BERENSHTEYN, Frada, LIU, Jun, QU, Xin, LEE, Cameron
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	C:\Usersczg\AppDaa\Roa ing\iManagc\Work\Rcen t\35570725AU 6-6 fusedbicywlIc, eroa l yco pounds ad thr us asLATS hibitor\Abstract as, field - 35570725(22281273 1).docx-7 12/2021 6-6 Fused Bicyclic Heteroaryl Compounds and their Use as LATS Inhibitors The present invention is related to 6-6 Fused Bicyclic Heteroaryl Compounds of the Formula A2 or Al and their Use as LATS Inhibitors, or a salt, stereoisomer or pharmaceutical composition thereof; wherein the variables are as defined herein. R1 R2 R1 R2 R5 N' R5 'N N-R N N-R Al N GI: The present invention further relates to a method of LATS inhibition in a cell population using a compound of Formula Al, or a salt, stereoisomer or pharmaceutical composition thereof. The present invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, their use in the treatment and management of diseases or disorders.