Antibody-containing formulation

Antibody-containing formulation

In a non-limiting embodiment, the present disclosure pertains to an antibody-containing formulation containing an anti-IL-6 receptor antibody as an active ingredient, the formulation containing a histidine-aspartate buffer or a histidine-glutamate buffer, Poloxamer 188, and arginine and having a pH...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YASUTAKE, Masaya, WATANABE, Atsushi, FUKUDA, Masakazu, HAYASAKA, Akira, KAMEOKA, Daisuke, IGAWA, Tomoyuki, IMAI, Chifumi
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:In a non-limiting embodiment, the present disclosure pertains to an antibody-containing formulation containing an anti-IL-6 receptor antibody as an active ingredient, the formulation containing a histidine-aspartate buffer or a histidine-glutamate buffer, Poloxamer 188, and arginine and having a pH of 5.5-6.6. In a non-limiting embodiment, the present disclosure pertains to a method for stabilizing an antibody-containing solution, a method for suppressing the association (for example, dimerization) of antibodies, and a method for suppressing the production of insoluble particles, the methods being characterized by involving: adding L-aspartic acid or L-glutamic acid; and optionally adding Poloxamer 188.