Imidazopyrrolopyridine as inhibitors of the JAK family of kinases

Imidazopyrrolopyridine as inhibitors of the JAK family of kinases

Abstract 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H) yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, 5 disorders, and conditions mediated by JAK, such as in...

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Hauptverfasser: Koudriakova, Tatiana, Krawczuk, Paul J, Seierstad, Mark, Kreutter, Kevin D, Rizzolio, Michele C, Bacani, Genesis M, Chai, Wenying, Tichenor, Mark S, Smith, Russel C, Wang, Aihua, Leonard, Kristi, Venable, Jennifer D
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Abstract 2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H) yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, 5 disorders, and conditions mediated by JAK, such as inflammatory bowel disease.