IMPLANTABLE MEDICAL DEVICES AND METHODS FOR REAL-TIME OR NEAR REAL-TIME ADJUSTMENT OF DIAPHRAGMATIC STIMULATION PARAMETERS TO AFFECT PRESSURES WITHIN THE INTRATHORACIC CAVITY

A controller detects a cyclic cardiac event of the patient based on a signal obtained from one or more electrodes configured for placement on or near a diaphragm, and delivers an electrical stimulation therapy to a diaphragm of the patient through the one or more electrodes. The delivery of electrical stimulation therapy is timed to the detection of the cyclic cardiac event, and the electrical stimulation therapy is defined by stimulation parameters. The controller monitors a pressure associated with the intrathoracic cavity of the patient based on a signal provided by a pressure measurement source configured to provide a signal indicative of a pressure within an intrathoracic cavity, to determine whether an adjustment of one or more of the stimulation parameters is warranted. Figure 6A Derive a measure of interest from each obtained heart sound signals (from FIG. 5A, block 510) Detect an occurrence of a first cardiac ,530 event based on one of the heart sound signal or a cardiac electrical activity signal Process the heart sound signal to detect an occurrence of a second cardiac event Determine the measure of interest as the time between the occurrence of the first cardiac event and the occurrence of the second cardiac event Select optimal stimulation therapy (return to FIG. 5A, block 512)