Compositions and methods for treatment of Acute Respiratory Distress Syndrome

Compositions and methods for treatment of Acute Respiratory Distress Syndrome

This invention relates generally to monoclonal antibodies or antigen binding fragments thereof that specifically bind Toll-like Receptor 4 (TLR-4), to methods of using the anti-TLR4 antibodies to treat or prevent symptoms of Acute Respiratory Distress Syndrome (ARDS). This invention also relates to...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GORDON, Blair Richard George, BROOKS, Michael John, NIJHAWAN, Pardeep
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention relates generally to monoclonal antibodies or antigen binding fragments thereof that specifically bind Toll-like Receptor 4 (TLR-4), to methods of using the anti-TLR4 antibodies to treat or prevent symptoms of Acute Respiratory Distress Syndrome (ARDS). This invention also relates to monoclonal antibodies or antigen binding fragments thereof that specifically bind to IP-10 and methods of using anti-IL-10 antibodies to treat or prevent symptoms of ARDS. The invention further provides routes of administrations and formulations for said methods.