Method for preparing 3'-O-amino-2'-deoxyribonucleoside-5'-triphosphates

Method for preparing 3'-O-amino-2'-deoxyribonucleoside-5'-triphosphates

The invention relates to a method for preparing 3'-O-amino-2'-deoxyribonucleoside- 5'-triphosphates with reduced 3'-hydroxy-2'-deoxyribonucleoside-5'-triphosphate contamination by converting 3'-(N-acetone-oxime)-2'-deoxynucleoside triphosphate to 3'-O- am...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YBERT, Thomas, WOJCIECHOWSKI, Filip
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:The invention relates to a method for preparing 3'-O-amino-2'-deoxyribonucleoside- 5'-triphosphates with reduced 3'-hydroxy-2'-deoxyribonucleoside-5'-triphosphate contamination by converting 3'-(N-acetone-oxime)-2'-deoxynucleoside triphosphate to 3'-O- amine-2'-deoxynucleoside triphosphate by treatment with an aryl-oxyamine.