P2X7 modulators

The present invention is directed to compounds of Formulas (I, la, Ila and Ilb): o R3 "X Formula (I) & Formula (la) o R3 R6 0 R3 RR N RI N-R 6 Formula (Ila) Formula (lb) The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, la, Ila and Ilb). Methods...

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Bibliographische Detailangaben
Hauptverfasser:	Alcazar Vaca, Manuel Jesus, Allison, Brett D, Wall, Jessica L, Deng, Xiaohu, Andres Gil, Jose Ignacio, Mani, Neelakandha S, Chrovian, Christa C, Swanson, Devin M, Coate, Heather R, Rech, Jason C, Dvorak, Curt A, Stenne, Brice M, Letavic, Michael A, De Angelis, Meri, Liang, Jimmy T, Soyode-Johnson, Akinola, Gelin, Christine F, Savall, Brad M
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to compounds of Formulas (I, la, Ila and Ilb): o R3 "X Formula (I) & Formula (la) o R3 R6 0 R3 RR N RI N-R 6 Formula (Ila) Formula (lb) The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, la, Ila and Ilb). Methods of making and using the compounds of Formulas (I, la, Ila and Ilb) are also within the scope of the invention.