Tim protein-bound carrier, methods for obtaining, removing and detecting extracellular membrane vesicles and viruses using said carrier, and kit including said carrier

The present invention addresses the problem of providing a carrier and method for simply and efficiently obtaining or removing extracellular membrane 5 vesicles or viruses present in a sample with high purity while keeping the vesicles or viruses intact, or detecting such vesicles or viruses with hi...

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Bibliographische Detailangaben
Hauptverfasser: HANAYAMA, Rikinari, NISHIBU, Takahiro, IMAWAKA, Naoko, NARUSE, Ken
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention addresses the problem of providing a carrier and method for simply and efficiently obtaining or removing extracellular membrane 5 vesicles or viruses present in a sample with high purity while keeping the vesicles or viruses intact, or detecting such vesicles or viruses with high sensitivity. The present invention relates to: "1. a carrier (Tim carrier) with which a protein (Tim protein) selected from T-cell immunoglobulin and mucin domain containing molecule-4 (Tim-4) protein, Tim-3 protein, and Tim-1 protein, is 10 bound; 2. a method for obtaining extracellular membrane vesicles or viruses in a sample; 3. a method for removing extracellular membrane vesicles or viruses in a sample; 4. a method for detecting extracellular membrane vesicles or viruses in a sample; 5. a kit for capturing extracellular membrane vesicles or viruses, wherein the kit includes the Tim carrier; and 6. a kit for capturing 15 extracellular membrane vesicles or viruses, wherein the kit includes a reagent containing the Tim protein and a reagent containing the carrier".