CD19-directed chimeric antigen receptor T cell compositions and methods and uses thereof
Provided in some aspects are compositions of cells for treating subjects with disease and conditions such as non-Hodgkin's lymphoma (NHL), and related methods, compositions, uses and articles of manufacture. In some embodiments, the disease or condition is a B-cell non-Hodgkin lymphoma (B-cell...
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| creator | BRIGGS, Adrian Wrangham CHAN, Calvin WESTOBY, Matthew BASHOUR, Keenan HEGE, Kristen GERMEROTH, Lothar SALMON, Ruth Amanda VARUN, Divya WU, Kaida KUGLER, David G POLTORAK, Mateusz Pawel KILAVUZ, Nurgul BATUREVYCH, Oleksandr CASPARY, Robert Guy BURGESS, Michael STEMBERGER, Christian |
| description | Provided in some aspects are compositions of cells for treating subjects with disease and conditions such as non-Hodgkin's lymphoma (NHL), and related methods, compositions, uses and articles of manufacture. In some embodiments, the disease or condition is a B-cell non-Hodgkin lymphoma (B-cell NHL). The cells generally express recombinant receptors such as chimeric antigen receptors (CARs) for targeting an antigen, such as CD 19, on cells of the lymphoma. |
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In some embodiments, the disease or condition is a B-cell non-Hodgkin lymphoma (B-cell NHL). 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In some embodiments, the disease or condition is a B-cell non-Hodgkin lymphoma (B-cell NHL). The cells generally express recombinant receptors such as chimeric antigen receptors (CARs) for targeting an antigen, such as CD 19, on cells of the lymphoma.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | CD19-directed chimeric antigen receptor T cell compositions and methods and uses thereof |
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