CD19-directed chimeric antigen receptor T cell compositions and methods and uses thereof

CD19-directed chimeric antigen receptor T cell compositions and methods and uses thereof

Provided in some aspects are compositions of cells for treating subjects with disease and conditions such as non-Hodgkin's lymphoma (NHL), and related methods, compositions, uses and articles of manufacture. In some embodiments, the disease or condition is a B-cell non-Hodgkin lymphoma (B-cell...

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Bibliographische Detailangaben
Hauptverfasser: BRIGGS, Adrian Wrangham, CHAN, Calvin, WESTOBY, Matthew, BASHOUR, Keenan, HEGE, Kristen, GERMEROTH, Lothar, SALMON, Ruth Amanda, VARUN, Divya, WU, Kaida, KUGLER, David G, POLTORAK, Mateusz Pawel, KILAVUZ, Nurgul, BATUREVYCH, Oleksandr, CASPARY, Robert Guy, BURGESS, Michael, STEMBERGER, Christian
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Provided in some aspects are compositions of cells for treating subjects with disease and conditions such as non-Hodgkin's lymphoma (NHL), and related methods, compositions, uses and articles of manufacture. In some embodiments, the disease or condition is a B-cell non-Hodgkin lymphoma (B-cell NHL). The cells generally express recombinant receptors such as chimeric antigen receptors (CARs) for targeting an antigen, such as CD 19, on cells of the lymphoma.