DNA-peptide combination vaccine

Abstract The present invention provides a pharmaceutical preparation that is a combination pharmaceutical 5 preparation for inducing a specific immune response to an antigenic peptide, wherein: the pharmaceutical preparation comprises (I) the antigenic peptide and (II) an expression vector that enco...

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Bibliographische Detailangaben
Hauptverfasser:	NAOHARA, Kenji, KORIYAMA, Hiroshi, TOMIOKA, Hideki, NAKAGAMI, Hironori, MORISHITA, Ryuichi
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Abstract The present invention provides a pharmaceutical preparation that is a combination pharmaceutical 5 preparation for inducing a specific immune response to an antigenic peptide, wherein: the pharmaceutical preparation comprises (I) the antigenic peptide and (II) an expression vector that encodes a chimera hepatitis B virus core antigen polypeptide to which the antigenic 10 peptide has been inserted or added, the antigenic peptide being inserted into the region of amino acid residues 74 - 87 or 130 - 138 of the hepatitis B virus core antigen polypeptide or added to the N terminal or C terminal of the hepatitis B virus core antigen polypeptide; and the 15 antigenic peptide (I) and the expression vector (II) are given substantially simultaneously administered to an application subject.