Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders
Abstract The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4)2, 0, NR4, S, S(R4), or S(R4)2 . x...
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| creator | BRUGGER, Nadia SHERER, Brian A |
| description | Abstract The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4)2, 0, NR4, S, S(R4), or S(R4)2 . x t(R5 ) (R4)r I- (I) n(R2) A B (R3)p (R1 )k |
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In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4)2, 0, NR4, S, S(R4), or S(R4)2 . x t(R5 ) (R4)r I- (I) n(R2) A B (R3)p (R1 )k</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231005&DB=EPODOC&CC=AU&NR=2021218041B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231005&DB=EPODOC&CC=AU&NR=2021218041B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRUGGER, Nadia</creatorcontrib><creatorcontrib>SHERER, Brian A</creatorcontrib><title>Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders</title><description>Abstract The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4)2, 0, NR4, S, S(R4), or S(R4)2 . x t(R5 ) (R4)r I- (I) n(R2) A B (R3)p (R1 )k</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNirsKwjAUQLM4iPoPd3AVmyi0qxXFwUFKnUtIbjWQR8m9Hfr3WvADnM7hcJaieSQ_mcl4Z6C9N-W-Ah1Zv1J0xPR1CyMh8Bszph5cnBU4o-aAkWFuIYwRwTpK2WKmtVj02hNuflyJ7fXSnm87HFKHNGiDEbk7PVWhpJJVcZR1rQ5_bh__iji7</recordid><startdate>20231005</startdate><enddate>20231005</enddate><creator>BRUGGER, Nadia</creator><creator>SHERER, Brian A</creator><scope>EVB</scope></search><sort><creationdate>20231005</creationdate><title>Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders</title><author>BRUGGER, Nadia ; SHERER, Brian A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2021218041BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BRUGGER, Nadia</creatorcontrib><creatorcontrib>SHERER, Brian A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRUGGER, Nadia</au><au>SHERER, Brian A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders</title><date>2023-10-05</date><risdate>2023</risdate><abstract>Abstract The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4)2, 0, NR4, S, S(R4), or S(R4)2 . x t(R5 ) (R4)r I- (I) n(R2) A B (R3)p (R1 )k</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders |
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