Polycyclic TLR7/8 antagonists and use thereof in the treatment of immune disorders

Abstract The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4)2, 0, NR4, S, S(R4), or S(R4)2 . x...

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Bibliographische Detailangaben
Hauptverfasser:	BRUGGER, Nadia, SHERER, Brian A
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Abstract The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as toll-like receptor 7/8 (TLR7/8) antagonists. In Formula (I), Ring A is aryl or heteroaryl; Ring B is aryl or heteroaryl; and X is C(R4)2, 0, NR4, S, S(R4), or S(R4)2 . x t(R5 ) (R4)r I- (I) n(R2) A B (R3)p (R1 )k