Antisense oligonucleotide of ATN1

Provided is an antisense oligonucleotide that controls the gene expression of ATN1 and can treat dentatorubropallidoluysian atrophy.　A compound containing a modified oligonucleotide consisting of 8 to 80 linked nucleosides and having a nucleobase sequence comprising at least 8 consecutive nucleobase...

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Bibliographische Detailangaben
Hauptverfasser:	HASHIMOTO, Shinji, GOTO, Izumi, IRIYAMA, Yusuke
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided is an antisense oligonucleotide that controls the gene expression of ATN1 and can treat dentatorubropallidoluysian atrophy.　A compound containing a modified oligonucleotide consisting of 8 to 80 linked nucleosides and having a nucleobase sequence comprising at least 8 consecutive nucleobases that are complementary to a transcript of ATN1, or a pharmacologically acceptable salt of the compound.