Methods of preparing inhibitors of influenza viruses replication

Methods of preparing inhibitors of influenza viruses replication

A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: N x H ' OH (1) comprises: (a) reacting Compound (X): (X or a B- 0 XN - -N Ts pharmaceutically acceptable salt thereof with Compound (Y): (Y) in the presence of a palladium catalyst and a carbonate or phosphate bas...

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Bibliographische Detailangaben
Hauptverfasser: TANOURY, Gerald J, ROSE, Peter Jamison, DVORNIKOVS, Vadims, NUGENT, William Aloysius
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A method of preparing Compound (1) or a pharmaceutically acceptable salt thereof: N x H ' OH (1) comprises: (a) reacting Compound (X): (X or a B- 0 XN - -N Ts pharmaceutically acceptable salt thereof with Compound (Y): (Y) in the presence of a palladium catalyst and a carbonate or phosphate base to form compound (Z): X1ix N " N NH O Ts N (Z) or a pharmaceutically acceptable salt thereof; and (b) deprotecting the Ts group of Compound (Z) to form Compound (1) or a pharmaceutically acceptable salt thereof.