Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity
The invention provides a compound of formula (I): R3 )s (R5)m (R'). OH 0 Het (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formu...
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| creator | MILLER, Duncan Charles WATSON, David Wyn MITCHELL, Dale Robert JOHNSON, Christopher Norbert PEACH, Joanne ST. DENIS, Jeffrey David CANO, Celine Florence WHITTAKER, Benjamin Paul HOLVEY, Rhian Sara LEWIS, Arwel CONS, Benjamin David BUCK, Ildiko Maria TAMANINI, Emiliano HARDCASTLE, Ian Robert OSBORNE, James Daniel HOWARD, Steven GOLDING, Bernard Thomas HIRST, Kim Louise REES, David Charles NOBLE, Martin Edward Mäntylä CHESSARI, Gianni GRIFFIN, Roger John |
| description | The invention provides a compound of formula (I): R3 )s (R5)m (R'). OH 0 Het (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. |
| format | Patent |
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DENIS, Jeffrey David ; CANO, Celine Florence ; WHITTAKER, Benjamin Paul ; HOLVEY, Rhian Sara ; LEWIS, Arwel ; CONS, Benjamin David ; BUCK, Ildiko Maria ; TAMANINI, Emiliano ; HARDCASTLE, Ian Robert ; OSBORNE, James Daniel ; HOWARD, Steven ; GOLDING, Bernard Thomas ; HIRST, Kim Louise ; REES, David Charles ; NOBLE, Martin Edward Mäntylä ; CHESSARI, Gianni ; GRIFFIN, Roger John</creator><creatorcontrib>MILLER, Duncan Charles ; WATSON, David Wyn ; MITCHELL, Dale Robert ; JOHNSON, Christopher Norbert ; PEACH, Joanne ; ST. DENIS, Jeffrey David ; CANO, Celine Florence ; WHITTAKER, Benjamin Paul ; HOLVEY, Rhian Sara ; LEWIS, Arwel ; CONS, Benjamin David ; BUCK, Ildiko Maria ; TAMANINI, Emiliano ; HARDCASTLE, Ian Robert ; OSBORNE, James Daniel ; HOWARD, Steven ; GOLDING, Bernard Thomas ; HIRST, Kim Louise ; REES, David Charles ; NOBLE, Martin Edward Mäntylä ; CHESSARI, Gianni ; GRIFFIN, Roger John</creatorcontrib><description>The invention provides a compound of formula (I): R3 )s (R5)m (R'). OH 0 Het (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. 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OH 0 Het (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. 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DENIS, Jeffrey David ; CANO, Celine Florence ; WHITTAKER, Benjamin Paul ; HOLVEY, Rhian Sara ; LEWIS, Arwel ; CONS, Benjamin David ; BUCK, Ildiko Maria ; TAMANINI, Emiliano ; HARDCASTLE, Ian Robert ; OSBORNE, James Daniel ; HOWARD, Steven ; GOLDING, Bernard Thomas ; HIRST, Kim Louise ; REES, David Charles ; NOBLE, Martin Edward Mäntylä ; CHESSARI, Gianni ; GRIFFIN, Roger John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2021202973BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2023</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>MILLER, Duncan Charles</creatorcontrib><creatorcontrib>WATSON, David Wyn</creatorcontrib><creatorcontrib>MITCHELL, Dale Robert</creatorcontrib><creatorcontrib>JOHNSON, Christopher Norbert</creatorcontrib><creatorcontrib>PEACH, Joanne</creatorcontrib><creatorcontrib>ST. 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DENIS, Jeffrey David</au><au>CANO, Celine Florence</au><au>WHITTAKER, Benjamin Paul</au><au>HOLVEY, Rhian Sara</au><au>LEWIS, Arwel</au><au>CONS, Benjamin David</au><au>BUCK, Ildiko Maria</au><au>TAMANINI, Emiliano</au><au>HARDCASTLE, Ian Robert</au><au>OSBORNE, James Daniel</au><au>HOWARD, Steven</au><au>GOLDING, Bernard Thomas</au><au>HIRST, Kim Louise</au><au>REES, David Charles</au><au>NOBLE, Martin Edward Mäntylä</au><au>CHESSARI, Gianni</au><au>GRIFFIN, Roger John</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity</title><date>2023-01-12</date><risdate>2023</risdate><abstract>The invention provides a compound of formula (I): R3 )s (R5)m (R'). OH 0 Het (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
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