Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity

The invention provides a compound of formula (I): R3 )s (R5)m (R'). OH 0 Het (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formu...

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Bibliographische Detailangaben
Hauptverfasser:	MILLER, Duncan Charles, WATSON, David Wyn, MITCHELL, Dale Robert, JOHNSON, Christopher Norbert, PEACH, Joanne, ST. DENIS, Jeffrey David, CANO, Celine Florence, WHITTAKER, Benjamin Paul, HOLVEY, Rhian Sara, LEWIS, Arwel, CONS, Benjamin David, BUCK, Ildiko Maria, TAMANINI, Emiliano, HARDCASTLE, Ian Robert, OSBORNE, James Daniel, HOWARD, Steven, GOLDING, Bernard Thomas, HIRST, Kim Louise, REES, David Charles, NOBLE, Martin Edward Mäntylä, CHESSARI, Gianni, GRIFFIN, Roger John
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention provides a compound of formula (I): R3 )s (R5)m (R'). OH 0 Het (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.