Substituted 3-Indazole MCL-1 Inhibitor, Preparation Method and Use Thereof

Substituted 3-Indazole MCL-1 Inhibitor, Preparation Method and Use Thereof

The present disclosure provides a substituted 3-indazole Mcl-i inhibitor, a preparation method and use thereof. The substituted 3-indazole Mcl-i inhibitor is a compound having the O / 'R2 NH structure of general formula (I): (1) . The compound disclosed by the present disclosure has relatively...

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Bibliographische Detailangaben
Hauptverfasser: WEN, Jiajun, YAN, Chunxing, LI, Yuanhua, WAN, Yichao
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides a substituted 3-indazole Mcl-i inhibitor, a preparation method and use thereof. The substituted 3-indazole Mcl-i inhibitor is a compound having the O / 'R2 NH structure of general formula (I): (1) . The compound disclosed by the present disclosure has relatively strong inhibitory activity against Mcl-i protein and may prevent or treat related mammalian diseases caused by aberrant expression of Mcl-i protein. The present disclosure further relates to pharmaceutical use of a composition containing the compound represented by the general formula (I).