An interleukin-1 receptor antagonist and a fusion protein containing the same

Provided is an Interleukin-1 Receptor Antagonist (IL-1RN) protein or a variant or analogue thereof, and a fusion protein comprising the following three-parts: the Interleukin-1 Receptor Antagonist protein or a variant or analogue thereof, a domain for half-life extension and an optional tumor necros...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	LIU, Yiren, LI, Shaokui, SUN, Yiping, LI, Ziqiang, MA, Rong, TIAN, Xinsheng
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Provided is an Interleukin-1 Receptor Antagonist (IL-1RN) protein or a variant or analogue thereof, and a fusion protein comprising the following three-parts: the Interleukin-1 Receptor Antagonist protein or a variant or analogue thereof, a domain for half-life extension and an optional tumor necrosis factor receptor 2, and the preparation method and use thereof. The above-mentioned protein mutant and fusion protein have the effects of extended half-life, improved affinity with interleukin-1 receptor and superior biological activity, and find use in the field of treatment and prevention of inflammatory-associated diseases.